Cystatin C as a surrogate for glomerular filtration rate in the presence of proteinuria
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Comparison of Serum Cystatin C and Creati-nine Levels to Evaluate Early Renal Function after Kidney Transplantation
Background: Accurate and rapid assessment of allograft function is essential in renal transplant recipients in order to detect allograft rejection and to monitor drug nephrotoxicity. We aimed to evaluate the usefulness of cystatin C as a marker of kidney allograft function in the early post-transplant period and to compare this value with that of conventional serum creatinine concentration. Met...
متن کاملSERUM CYSTATIN C AS A NEW MARKER OF GLOMERULAR FILTRATION RATE (GFR)
Cystatin C is a 13 KD basic protein that is a member of the cystatin superfamily of cysteine protease inhibitors. The cystatin C gene seems to be a house keeping gene, which is compatible with a stable production rate of cystatin C by most cells. This protein is freely filtered through the glomerulus and almost completely reabsorbed and catabolized by proximal tubular cells. Because of the...
متن کاملComparative Assessment of Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Cystatin C as Early Biomarkers for Early Detection of Renal Failure in Patients with Hypertension
Background: Hypertension is one the most common causes of chronic kidney disease (CKD). One of the major concerns in hypertensive patients is early detection of renal disorders. In the past, serum creatinine (Scr) concentration was used as a marker of kidney function, but it proffers a late reflection of reduced glomerular filtration rate. Cystatin C and neutrophil gelatinase-associated lipocal...
متن کاملGlomerular filtration rate determination by creatinine and cystatin-C in patients with acute pyelonephritis
Background: Measurement of glomerular filtration rate (GFR) and monitoring of it in any patient on nephrotoxic drugs is very important. Recently, cystatin C (cys-C) has been introduced as a better marker for determining and monitoring renal function than creatinine especially in a mild decrease of GFR. This study was done to assess the change of GFR measurement based on serum Cys-C and creatini...
متن کاملThe CARI Guidelines – Caring for Australians with Renal Impairment Evaluation of Renal Function
• There is no convincing evidence that serum cystatin C measurement offers any clinical advantage over estimated glomerular filtration rate (eGFR) (Level III evidence, small-to-medium observational cohort studies, surrogate outcomes, weak effect) except that serum cystatin C appears to be superior to both serum creatinine and eGFR as a predictor of cardiovascular events in the eldely (age ≥ 65 ...
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